- Alice Faye
- Emmy Jordan
- Warner Baxter
- Hank Topping
- Charles Winninger
- Samuel J. Cady
- Arthur Treacher
- Upton Ward
- Keye Luke
- Ling - Cady's Secretary
- Willie Fung
- Yen - Cady's Major Domo
- Doris Lloyd
- Mrs. Ward
- Eily Malyon
- Mrs. Little - Head of Mission
- Joan Carroll
- Winifred Ward
- Leonid Snegoff
- Boris - Russian Consul
- Philip Ahn
- Col. Wai Kang
- Jonathan Hale
- Assistant Secretary of State
- Moroni Olsen
- Shanghai Managing Editor
- Harry Hayden
- Shanghai Telegraph Manager
- Philson Ahn
- Trainman
- Martha Bamattre
- Swedish Woman on Train
- Edward Earle
- American Consul's Under-Secretary
- Lee Tong Foo
- Houseboy
- Chester Gan
- Mongol Bandit Leader
- William Law
- Train Conductor
- Eddie Lee
- Wah - Consulate Servant
- Richard Loo
- Colonel Commander of Rescue Party
- Shirley Louie
- Chinese Girl
- Paul McVey
- Copy Reader
- Louis Mercier
- Frenchman on Train
- Adolph Milar
- German on Train
- Ernesto Molinari
- Hindu on Train
- Lillie Mui
- Chinese Girl
- Mrs. Ng
- Old Chinese Woman
- Howard Soo Hoo
- Orphan
- Charles Tannen
- Opening Narrator
- Victor Wong
- Second Bandit
- Victor Sen Yung
- Undetermined Role
