- Melissa Disney
- Â Ginger Foutley / ... 54 episodes, 2000-2009
- Jeannie Elias
- Â Carl Foutley / ... 54 episodes, 2000-2009
- Tress MacNeille
- Â Hoodsey Bishop / ... 54 episodes, 2000-2009
- Aspen Vincent
- Â Dodie Bishop / ... 54 episodes, 2000-2009
- Jackie Harris Greenberg
- Â Macie Lightfoot / ... 53 episodes, 2000-2009
- Laraine Newman
- Â Lois Foutley / ... 49 episodes, 2000-2009
- Liz Georges
- Â Courtney Gripling / ... 38 episodes, 2000-2009
- Cree Summer
- Â Miranda Killgallen 37 episodes, 2000-2009
- Kenny Blank
- Â Darren Patterson / ... 33 episodes, 2000-2009
- Kath Soucie
- Â Blake Gripling / ... 33 episodes, 2000-2009
- Grey Griffin
- Â Brandon Higsby / ... 25 episodes, 2000-2009
- Susan Krebs
- Â Joann Bishop / ... 21 episodes, 2000-2006
- Elizabeth Halpern
- Â Ms. Zorski 17 episodes, 2000-2006
- Sandy Fox
- Â Mipsy Mipson 17 episodes, 2000-2004
- Jerry Houser
- Â Principal Milty / ... 15 episodes, 2000-2006
- John Kassir
- Â Winston / ... 14 episodes, 2000-2006
- Kathleen Freeman
- Â Mrs. Gordon 14 episodes, 2000-2003
- David Jeremiah
- Â Dr. Dave / ... 13 episodes, 2000-2009
- Hope Levy
- Â Chet Zipper / ... 12 episodes, 2000-2003
- Candi Milo
- Â Claire Gripling / ... 7 episodes, 2000-2002
- Tom Virtue
- Â Jonas Foutley 7 episodes, 2000-2004
- Guy Torry
- Â Will Patterson 7 episodes, 2000-2004
- Dee Bradley Baker
- Â Mr. Licorice / ... 7 episodes, 2000-2003
- Justin Cowden
- Â Orion 6 episodes, 2003-2009
- Erica Luttrell
- Â Simone / ... 6 episodes, 2003-2009
- Emily Kapnek
- Â Noelle Sussman 6 episodes, 2002-2004
- Dan Castellaneta
- Â Dave Bishop / ... 5 episodes, 2002-2004
- Jeffrey Buehl
- Â Dwayne Cochran / ... 5 episodes, 2001-2003
- Ja'net DuBois
- Â Mrs. Patterson 5 episodes, 2000-2004
- Michael Beattie
- Â Principal Erickson / ... 5 episodes, 2001-2009
- Patti Deutsch
- Â Mrs. Dave 4 episodes, 2004
- Billy Brown
- Â Mr. Patterson / ... 4 episodes, 2000-2003
- Adam Wylie
- Â Ian Richton 4 episodes, 2000-2001
- Andre Ware
- Â Mr. Hepper / ... 4 episodes, 2001-2004
- Ping Wu
- Â Archie Chang / ... 4 episodes, 2001-2004
- J. Evan Bonifant
- Â Sasha 3 episodes, 2001-2004
- Shawana Kemp
- Â Miss Zorski / ... 3 episodes, 2000-2009
- Lewis Arquette
- Â Mr. Cilia 3 episodes, 2000-2001
- Tom Kenny
- Â Buzz Harris 3 episodes, 2002-2004
- Ben Stein
- Â Buddy Baker 3 episodes, 2004-2009
- Shannon Conley
- Â Rock Chick / ... 3 episodes, 2001-2004
- Carol Kane
- Â Maude 2 episodes, 2000-2001
- John Astin
- Â Dave Bishop 2 episodes, 2001
- S. Scott Bullock
- Â Dr. Randall / ... 2 episodes, 2001-2003
- Nora Dunn
- Â Coach Candace / ... 2 episodes, 2004-2009
- Adrienne Frantz
- Â Computer Voice / ... 2 episodes, 2000
- Billy West
- Â Cleetis Boregard / ... 2 episodes, 2003
- Kimberly Brooks
- Â Chantel / ... 2 episodes, 2001-2004
- Katie Leigh
- Â Junior / ... 2 episodes, 2002-2004
- Eddie Barth
- Â Louie / ... 2 episodes, 2002-2003
- Mindy Sterling
- Â Ms. Powell / ... 2 episodes, 2002
- Crystal Scales
- Â Lonnie 2 episodes, 2000-2001
- Jim Meskimen
- Â Mr. Grundig / ... 2 episodes, 2003-2009
- Jennifer Paz
- Â Traci / ... 2 episodes, 2000
- Roberta Farkas
- Â Mrs. Lawrence / ... 2 episodes, 2002
- Andy Morris
- Â Student Messenger / ... 2 episodes, 2003-2009
- Amy Gross
- Â Anita 2 episodes, 2004-2009
- Richard McGonagle
- Â Officer Killgallen 2 episodes, 2000-2001
- Carol Rosenthal
- Â Margie 2 episodes, 2001-2004
- Craig Strong
- Â Delivery Boy / ... 2 episodes, 2000-2001
- Diane Michelle
- Â Dr. Fondfeelings 2 episodes, 2002
- Toran Caudell
- Â Fred 2 episodes, 2003
- Mary Gross
- Â Bobbie Lightfoot 1 episode, 2002
- Jennifer Coolidge
- Â Nikki LaPorte 1 episode, 2004
- Michael McKean
- Â Bobby Lightfoot 1 episode, 2002
- Cara DeLizia
- Â Laetitia Bowans 1 episode, 2002
- Jesse Corti
- Â Dr. Juan / ... 1 episode, 2002
- Mathew Valencia
- Â Joaquin Cortez 1 episode, 2002
- Tom Dixon
- Â Minister 1 episode, 2002
- Joey Lauren Adams
- Â Thea Mipson 1 episode, 2003
- Tara Strong
- Â Blake Gripling 1 episode, 2005
- Robbie Rist
- Â Steven Applebaum 1 episode, 2003
- David Thomas
- Â Farmer Don 1 episode, 2004
- Charlie Adler
- Â Principal / ... 1 episode, 2005
- Alex Dent
- Â Walker 1 episode, 2000
- Neil Patrick Harris
- Â Ned 1 episode, 2001
- Stacey Winkler
- Â Muffin 1 episode, 2001
- David Neil Black
- Â Ex-Extra Grande Triangle Player 1 episode, 2002
- Eric Loomis
- Â Mr. Gardner 1 episode, 2003
- Floyd Van Buskirk
- Â Raymo 1 episode, 2004
- Olivia Hack
- Â Hall Monitor 1 episode, 2000
- Kyle Gibson
- Â Cool Kid 1 episode, 2000
- Shawn Pyfrom
- Â James 1 episode, 2001
- Pamela Adlon
- Â Dustin 1 episode, 2002
- Lukas Haas
- Â Jake 1 episode, 2002
- Danny Mann
- Â Mr. Blauer 1 episode, 2002
- Charlie Dell
- Â Crazy Floyd 1 episode, 2002
- Quinton Flynn
- Â George Magrority 1 episode, 2002
- Susan Chesler
- Â Nancy 1 episode, 2004
- Eric Jungmann
- Â Chairlift Operator 1 episode, 2000
- Jamie Cronin
- Â Andrea 1 episode, 2001
- Anthony Jesse Cruz
- Â Soccer Buddy 1 episode, 2001
- R. Samantha Lee
- Â Lizzie 1 episode, 2001
- Robert Costanzo
- Â Chef Bob 1 episode, 2002
- Stuart Pankin
- Â Math Teacher / ... 1 episode, 2002
- Beth Howland
- Â Dr. Leventhal 1 episode, 2002
- Anndi McAfee
- Â Blonde Girl / ... 1 episode, 2002
- Nancy Linari
- Â Sobbing Patient 1 episode, 2002
- Ralph Votrian
- Â Doctor / ... 1 episode, 2002
- Heather D. Ryan
- Â Katie 1 episode, 2002
- Jane Wiedlin
- Â Hope Rogers 1 episode, 2003
- April Winchell
- Â Cleaning Lady 1 episode, 2004
- Paula Tiso
- Â Polly Shuster 1 episode, 2004
- Amy Danles
- Â Cheerleader #4 / ... 1 episode, 2004
- Mo Collins
- Â Nurse 1 episode, 2000
- Warren Sroka
- Â Jock 1 episode, 2000
- Greg Lewis
- Â Mr. Pringle 1 episode, 2000
- Arthur Burghardt
- Â Santa Claus #1 1 episode, 2001
- Kerrigan Mahan
- Â Ludlow Krantz / ... 1 episode, 2001
- LaTonya Holmes
- Â Teacher's Pet 1 episode, 2001
- Christina Pickles
- Â Carl's Art Teacher 1 episode, 2002
- Victor Wilson
- Â Mr. Ward 1 episode, 2002
- Paul Greenberg
- Â Naked Mole Rat Expert 1 episode, 2002
- Patrick Pinney
- Â Food Inspector / ... 1 episode, 2002
- Michael McGaharn
- Â Janitor / ... 1 episode, 2002
- Cristina Pucelli
- Â Vanessa 1 episode, 2004
- Brian Tochi
- Â Mr. Briggs / ... 1 episode, 2006
- Liza Del Gado
- Â Joan 1 episode, 2009
- Logan Taylor
- Â Heather 1 episode, 2000
- Danny Cooksey
- Â Lifeguard 1 episode, 2001
- Christopher Rodriguez Marquette
- Â Stuart Higsby 1 episode, 2001
- Sally Struthers
- Â Mrs. Bigsby 1 episode, 2002
- Sam McMurray
- Â Mr. Gripling / ... 1 episode, 2002
- Sam Saletta
- Â Guy / ... 1 episode, 2002
- Kevin Michael Richardson
- Â Jimmy 1 episode, 2004
- Rita Rudner
- Â Mrs. Fleming 1 episode, 2000
- Bernie Kopell
- Â Mr. Libby 1 episode, 2001
- Richard Steven Horvitz
- Â Mitchey Mickelberg 1 episode, 2001
- Tia Texada
- Â Villager #2 1 episode, 2001
- Suzanne Kent
- Â Mrs. Berger 1 episode, 2001
- Kiel Holmes
- Â Michael Ricci 1 episode, 2001
- Pat Harrington Jr.
- Â Arnie 1 episode, 2004
- Leandra Argyros
- Â Leandra 1 episode, 2004
- Terri Apple
- Â Film Narrator 1 episode, 2000
- Erik von Detten
- Â Kid #2 1 episode, 2001
- Andrew Lawrence
- Â Bathroom Chef 1 episode, 2001
- Kate Movius
- Â Giselle 1 episode, 2001
- Brian Cummings
- Â Principal Huliski / ... 1 episode, 2002
- John Mariano
- Â Delivery Man 1 episode, 2002
- Christopher John Fields
- Â Dr. Ron 1 episode, 2004
- Eryk Casemiro
- Â Cheese Attendant 1 episode, 2003
- Phil Reeves
- Â Anesthesiologist Al 1 episode, 2004
- Wes Campbell
- Â Bus Driver 1 episode, 2003
- Tony Plana
- Â Spanish Doctor 1 episode, 2001
- Chris Parnell
- Â Radio Announcer / ... 1 episode, 2003
- Valerie Harper
- Â Librarian / ... 1 episode, 2004
- Lauren Tom
- Â Hip Art Student 1 episode, 2003
- Gregory Jbara
- Â Delivery Man 1 episode, 2004
- Billie Worley
- Â Camera Guy 1 episode, 2004
- Estelle Harris
- Â Myrna 1 episode, 2004
- Larry Drake
- Â Dr. Weinstein 1 episode, 2002
- Rino Romano
- Â Radio Announcer / ... 1 episode, 2003
- Cutter Garcia
- Â Mr. Minor 1 episode, 2004
- Bradley Pierce
- Â Darren Patterson 1 episode, 2005