- Fredric March
- Anthony Adverse
- Olivia de Havilland
- Angela Guisseppi
- Donald Woods
- Vincent Nolte
- Anita Louise
- Maria
- Edmund Gwenn
- John Bonnyfeather
- Claude Rains
- Don Luis
- Louis Hayward
- Denis Moore
- Gale Sondergaard
- Faith
- Steffi Duna
- Neleta
- Billy Mauch
- Anthony Adverse at ten
- Akim Tamiroff
- Carlo Cibo
- Ralph Morgan
- Debruille
- Henry O'Neill
- Father Xavier
- Pedro de Cordoba
- Brother Francois
- George E. Stone
- Sancho
- Luis Alberni
- Tony Guisseppi
- Fritz Leiber
- Ouvrard
- Joseph Crehan
- Capt. Elisha Jorham
- Rafaela Ottiano
- Signora Buvino
- Rollo Lloyd
- Napoleon Bonaparte
- Leonard Mudie
- De Bourrienne
- Marilyn Knowlden
- Florence Udney
- Mathilde Comont
- Cook Guisseppi
- Eily Malyon
- Mother Superior
- J. Carrol Naish
- Major Doumet
- Scotty Beckett
- Anthony's Son
- Paul Sotoff
- Ferdinando
- Frank Reicher
- Coach Driver to Paris
- Clara Blandick
- Mrs. Jorham
- Addison Richards
- Capt. Matanaza
- William Ricciardi
- Coachman to Leghorn
- Grace Stafford
- Lucia
- Panchita Acosta
- Italian Girl
- Sam Appel
- Driver / Arab (uncredited)
- Barlowe Borland
- Clerk at Bonnyfeather's
- Egon Brecher
- Innkeeper
- Helen Brown
- Lady at Ball
- Ann Bupp
- Dancer
- David Cavendish
- Napoleon's Secretary
- Davison Clark
- Traveler
- Dan Colette
- Usher
- Philip Cooper
- Stable Boy
- Albert Milton Cranston
- Man
- Guy D'Ennery
- Majordomo
- Carrie Daumery
- Lady at Ball
- Jean De Briac
- Stranger
- Carlos De Valdez
- Cuban Policeman
- Juan Duval
- Pietro
- Charles Fallon
- Traveler
- Antonio Filauri
- Undetermined Secondary Role
- Bess Flowers
- Nun
- Brenda Fowler
- Midwife at Anthony's Birth
- Martin Garralaga
- Arab
- Marjorie Gateson
- Undetermined Secondary Role
- Octavio Giraud
- Driver
- Robert Graves
- Officer
- Joe Hachey
- Marco
- Anne Howard
- Angela - as a Child
- John Lester Johnson
- Native Chief
- Edward Keane
- Officer
- Joe King
- Captain of Ship to America
- Walter Kingsford
- Undetermined Secondary Role
- Frank Lackteen
- Arab
- Mitchell Lewis
- White Man Whipping Slave
- Alma Lloyd
- Undetermined Secondary Role
- Manuel López
- Arab
- Fred Malatesta
- Stranger
- Michael Mark
- Stage-Door Man
- Myra Marsh
- Nun
- Ray Martin
- Young Slave
- Billy McClain
- Black Slave Being Whipped
- Lal Chand Mehra
- Arab
- Art Miles
- Dock Hand at Leghorn
- Ferdinand Munier
- Doctor at Baths
- Ottola Nesmith
- Sister Ursula
- Boris Nicholai
- Courier
- Artemus Nigolian
- Italian Girl
- Claude Payton
- Announcer of Guests at Ball
- George Reed
- Crippled Black Man
- Jimmy Robinson
- Black Man
- Harry Semels
- Lottery Celebrant
- Frank Shannon
- Majordomo
- Bernard Siegel
- Pablo
- George Sorel
- Footman
- Mike Tellegen
- Italian Man
- Arthur Thalasso
- Italian Man
- Lotus Thompson
- Lady at Ball
- Cyril Thornton
- Undetermined Secondary Role
- Zeffie Tilbury
- Old Woman at Chalet
- Vivian Tobin
- Lady at Ball
- Martin Turner
- Black Carriage Driver
- Frank Ward
- Traveler
- Pat Washington
- Old Slave
- Paul Weigel
- Butler
- Lottie Williams
- Nurse to Anthony's Son
- Ernest Wilson
- Anthony's Black Slave
- Joan Woodbury
- Half-Caste Dancing Girl
