- Geena Davis
- Angie
- Stephen Rea
- Noel
- James Gandolfini
- Vinnie
- Aida Turturro
- Tina
- Philip Bosco
- Frank
- Jenny O'Hara
- Kathy
- Michael Rispoli
- Jerry
- Betty Miller
- Joanne
- Susan Jaffe
- Ballerina
- Jeremy Collins
- Lover
- Robert Conn
- Death
- Ray Xifo
- Dr. Gould
- Rosemary De Angelis
- Aunt Vicky
- Rae Allen
- Aunt Violetta
- Ida Bernardini
- Aunt Louisa
- Frank Pellegrino
- Uncle Marty
- Michael Laskin
- Surgeon
- Jean Marie Barnwell
- Young Angie
- Elaine Kagan
- Aunt Jean
- Olga Merediz
- Roz
- Marylouise Burke
- Fern
- Mike Jefferson
- Tony
- Marin Hinkle
- Young Joanne
- Nancy Giles
- Bedside Nurse
- Antoinette Peragine
- Circulating Nurse
- Charlayne Woodard
- Floor Nurse
- Adam LeFevre
- Museum Guard
- Michael Goldfinger
- Director
- Joanne Baron
- ICU Nurse #1
- April Grace
- ICU Nurse #2
- Vernee Watson
- ICU Desk Nurse
- Bibi Osterwald
- Dr. Gould's Nurse
- Robbie Wenger
- Boy in Park
- Matt Hofherr
- Coffee Shop Waiter
- Louis Gigante
- Priest
- Joanna Sanchez
- Admissions Nurse #1
- Margaret Cho
- Admissions Nurse #2
- Anthony Baracco
- Tina's Son #1
- Leonard Spinelli
- Tina's Son #2
- John Toles-Bey
- Hospital Guard
- Eileen Davis
- Cranky Labor Nurse
- Roseanne Tucci
- Bernadette
- Maria Venusio
- Denise
- Marie Coluccio
- Nicole
- Lauren Cona
- Donna
- Marya Delia Javier
- Alba
- Diane DiLascio
- Lori
- Dawn Hudson
- Woman on Bus
- James Plair
- Bus Driver
- Simone Study
- Woman at Bar
- Ron Michaels
- Mechanic #1
- Tony Ray Rossi
- Mechanic #2
- Sharon Claveau
- Woman in Window
- Marc Allen Lewis
- Man in Wheelchair
- Lena Banks
- Art Museum Patron
- Mike George
- Musician
- Matthew T. Gitkin
- Fish Store Assistant
- Ash Sroka
- Young Tina
- Irene Wiley
- ICU Nurse
