- Arsenio Hall
- Apartment Victim (segment "Mondo Condo")
- Donald F. Muhich
- Easterbrook (segment "Pethouse Video")
- Monique Gabrielle
- Taryn Steele (segment "Pethouse Video")
- Lou Jacobi
- Murray (segment "Murray in Videoland")
- Erica Yohn
- Selma (segment "Murray in Videoland")
- Debbi A. Davison
- Weatherperson (segment "Murray in Videoland")
- Rob Krausz
- Floor Manager (segment "Murray in Videoland")
- Phil Hartman
- Baseball Announcer (segment "Murray in Videoland")
- Corey Burton
- Anchorman (segment "Murray in Videoland") / TV Announcer (segment "Amazon Women on the Moon") / Announcer (segment "Silly Pate") (voice)
- Michelle Pfeiffer
- Brenda Landers (segment "Hospital")
- Peter Horton
- Harry Landers (segment "Hospital")
- Griffin Dunne
- Doctor (segment "Hospital")
- Brian Ann Zoccola
- Nurse (segment "Hospital")
- Joe Pantoliano
- Sy Swerdlow (segment "Hairlooming")
- Stanley Brock
- Customer (segment "Hairlooming")
- Steve Forrest
- Capt. Steve Nelson (segment "Amazon Women on the Moon")
- Robert Colbert
- Blackie (segment "Amazon Women on the Moon")
- Joey Travolta
- Butch (segment "Amazon Women on the Moon")
- Forrest J. Ackerman
- U.S. President (segment "Amazon Women on the Moon")
- Sybil Danning
- Queen Lara (segment "Amazon Women on the Moon")
- Lana Clarkson
- Alpha Beta (segment "Amazon Women on the Moon")
- David Alan Grier
- Don 'No Soul' Simmons (segment "Blacks Without Soul,' 'Don 'No Soul' Simmons")
- B.B. King
- Self (segment "Blacks Without Soul")
- William Bryant
- Male Republican (segment "Blacks Without Soul")
- Roxie Roker
- Female Republican (segment "Blacks Without Soul")
- Le Tari
- Pimp (segment "Blacks Without Soul")
- Christopher Broughton
- Fan Club President (segment "Blacks Without Soul")
- Rosanna Arquette
- Karen (segment "Two I.D.'s")
- Steve Guttenberg
- Jerry (segment "Two I.D.'s")
- Henry Silva
- Henry Silva (segment "Bullshit or Not")
- Sarah Lilly
- Prostitute (segment "Bullshit or Not")
- Archie Hahn
- Harvey Pitnik (segment "Critic's Corner,' 'Roast Your Loved One")
- Belinda Balaski
- Bernice Pitnik (segment "Critic's Corner' 'Roast Your Loved One")
- Justin Benham
- Pitnik Boy (segment "Critic's Corner,' 'Roast Your Loved One")
- Erica Gayle
- Pitnik Girl (segment "Critic's Corner,' 'Roast Your Loved One")
- Al Lohman
- Frankel (segment "Critic's Corner")
- Roger Barkley
- Herbert (segment "Critic's Corner")
- T.K. Carter
- Host (segment "Silly Pate")
- Phil Proctor
- Mike (segment "Silly Pate")
- Ira Newborn
- Fred (segment "Silly Pate")
- Karen Montgomery
- Karen (segment "Silly Pate")
- Robert Picardo
- Rick Raddnitz (segment "Roast Your Loved One")
- Rip Taylor
- Rip Taylor (segment "Roast Your Loved One")
- Slappy White
- Slappy White (segment "Roast Your Loved One")
- Jackie Vernon
- Jackie Vernon (segment "Roast Your Loved One")
- Henny Youngman
- Henny Youngman (segment "Roast Your Loved One")
- Charlie Callas
- Charlie Drake (segment "Roast Your Loved One")
- Steve Allen
- Steve Allen (segment "Roast Your Loved One")
- William Marshall
- Pirate Captain (segment "Video Pirates")
- Tino Insana
- Mr. Sylvio (segment "Video Pirates")
- Donald Gibb
- Graceless Pirate (segment "Video Pirates")
- Frank Collison
- Grizzled Pirate (segment "Video Pirates")
- William S. Taylor
- Gruesome Pirate (segment "Video Pirates")
- Ed Begley Jr.
- Griffin (segment "Son of the Invisible Man") / Station Announcer (segment "Amazon Women on the Moon")
- Chuck Lafont
- Trent (segment "Son of the Invisible Man")
- Pamla Vale
- Woman in Pub (segment "Son of the Invisible Man")
- Larry Hankin
- Man in Pub (segment "Son of the Invisible Man")
- Garry Goodrow
- Checker Player (segment "Son of the Invisible Man")
- Roger La Page
- London Bobby (segment "Son of the Invisible Man")
- John Ingle
- Felix Van Dam (segment "Art Sale")
- Angel Tompkins
- First Lady (segment "First Lady of the Evening")
- Terence McGovern
- Salesman (segment "First Lady of the Evening")
- Michael Hanks
- Announcer (segment "First Lady of the Evening")
- Matt Adler
- George (segment "Titan Man")
- Kelly Preston
- Violet (segment "Titan Man")
- Ralph Bellamy
- Mr. Gower (segment "Titan Man")
- Howard Hesseman
- Rupert King (segment "Titan Man")
- Steve Cropper
- Customer (segment "Titan Man")
- Marc McClure
- Ray (segment "Video Date")
- Russ Meyer
- Video Salesman (segment "Video Date")
- Corinne Wahl
- Sherrie (segment "Video Date")
- Andrew Dice Clay
- Frankie (segment "Video Date")
- Willard E. Pugh
- Speaking Cop (segment "Video Date")
- Carrie Fisher
- Mary Brown (segment "Reckless Youth")
- Paul Bartel
- Doctor (segment "Reckless Youth")
- Herb Vigran
- Agent (segment "Reckless Youth")
- Tracy Hutchinson
- Floozie (segment "Reckless Youth")
- Mike Mazurki
- Dutch (segment "Reckless Youth")
- Frank Beddor
- Ken (segment "Reckless Youth")
- Jenny Agutter
- Cleopatra (segment "Peter Pan Theatre" [TV cut & DVD only])
- Raye Birk
- Vanya (segment "Peter Pan Theatre" [TV cut & DVD only])
- Vivian Bonnell
- Theatre Customer #3 (segment "Peter Pan Theatre" [TV cut & DVD only])
- Mark Bringelson
- Theatre Customer #1 (segment "Peter Pan Theatre" [TV cut & DVD only])
- Philip Bruns
- Manager (segment "The French Ventiloquist's Dummy" [TV cut & DVD only])
- Bernie Casey
- Maj. Gen. Hadley (segment "The Unknown Soldier" [TV cut & DVD only])
- Ronny Cox
- Gen. Balentine (segment "The Unknown Soldier" [TV cut & DVD only])
- Bryan Cranston
- Paramedic #1 (segment "Roast Your Loved One")
- Martin Goslins
- French Ventriloquist (segment "The French Ventiloquist's Dummy" [TV cut & DVD only])
- David E. Harshbarger
- The Claw (closing credits)
- Kelly
- Nurse (segment "Hospital")
- Marie Lamarre
- Model
- Wallace Langham
- Private Anson W. Pucket (segment "The Unknown Soldier" [TV cut & DVD only])
- Huey Lewis
- Self (segment "Murray in Videoland")
- Victoria Ann Lewis
- Theatre Customer #2 (segment "Peter Pan Theatre" [TV cut & DVD only])
- Robert Loggia
- Gen. McCormick (segment "The Unknown Soldier" [TV cut & DVD only])
- Bela Lugosi
- Pete Jones (segment "Reckless Youth")
- Kevin Marcy
- Secret Service Agent (segment "Murray in Videoland")
- Paul McMichael
- Daughter at sperm bank (Lifescenes Magazine Celebrity Sperm Bank)
- Dick Miller
- Danny Clayton (segment "The French Ventiloquist's Dummy" [TV cut & DVD only])
- Kellye Nakahara
- Theatre Customer #4 (segment "Peter Pan Theatre" [TV cut & DVD only])
- Dan Seymour
- Dr. Muggs McGinty (Segment "Reckless Youth" Blu-ray DVD Only)
- Robina Suwol
- Woman
- Lyle Talbot
- Prescott Townsend (segment "Amazon Women on the Moon")
- USC Trojan Marching Band
- Marching Band (segment "Titan Man")
- Christopher Wolf
- Mascot 'Bip' (segment "Titan Man")
- Michael Young
- Lifescenes Magazine - Jim Scott
