- Sean Connery
- Alexander, King of Macedon
- Margaretta Scott
- The Queen Mother
- William Russell
- Hephaestion
- Lyndon Brook
- Philotas
- Paul Stassino
- King Darius
- William Devlin
- Parmenion, Philotas' father
- Alan Tilvern
- Prince Bessus, Satrap of Bactria
- Alex Scott
- Ptolemy
- Edward Cast
- Perdiccas
- Michael Brennan
- Father Cleitus
- Noel Hood
- The Pythla, Priestess of Apollo
- Walter Brown
- Polystratos
- Ann Dimitri
- Queen Statira
- Pauline Knight
- Princess Statira
- Bandana Das Gupta
- Roxana
- Tutte Lemkow
- Mazares, the King's Chamberlain
- Walter Randall
- Palace Official
