- Darrell Hammond
- Annoucer
- Don Pardo
- Announcer
- Fred Armisen
- Lawrence Welk / Queen Elizabeth / Norada (archive footage) (uncredited)
- Vanessa Bayer
- Self / Baby Shower guest / friend (archive footage) (uncredited)
- Beck Bennett
- Self
- Aidy Bryant
- Self / Baby Shower guest / doctor / Jackie / Janelle (archive footage) (uncredited)
- Michael Che
- Self - Weekend Update Anchor
- Patricia Clarkson
- Mother
- Pete Davidson
- Self / Cutiepie Paul (archive footage) (uncredited)
- Mikey Day
- Father / John-Christopher / husband (archive footage) (uncredited)
- Rachel Dratch
- Jugglette / Mom Jeans mother (archive footage) (uncredited)
- Zac Efron
- Gino's Pizza Rolls actor
- Abby Elliott
- Mom Celebrity Translator daughter / Ashley (archive footage) (uncredited)
- Will Ferrell
- Craig Buchanan
- Tina Fey
- Jugglette / Mom Jeans mother (archive footage) (uncredited)
- Will Forte
- Gary Corndeensen / friend (archive footage) (uncredited)
- Heidi Gardner
- Deesa / mother (archive footage) (uncredited)
- Ana Gasteyer
- Clara / nurse (archive footage) (uncredited)
- Bill Hader
- Alan Farthington / Father / Mom Celebrity Translator son / Nelson's Baby Toupees spokesperson / friend / Stefon (archive footage) (uncredited)
- Phil Hartman
- Eugene the Anal Retentive Chef
- Jennifer Love Hewitt
- Alexis Murphy
- Jan Hooks
- Eugene the Anal Retentive Chef's mother
- Adam Horovitz
- Bobby Dimitri
- Colin Jost
- Weekend Update Anchor
- AJ Kane
- Son
- Brie Larson
- Baby Shower mother
- Taylor Lautner
- Alex
- Kate McKinnon
- Self / Baby Shower guest / Ebisaleth / Mother (archive footage) (uncredited)
- Seth Meyers
- Weekend Update Anchor
- Alex Moffat
- Doctor
- Kyle Mooney
- Self
- Bobby Moynihan
- Self / Royal Guard / Mom Celebrity Translator son / Paul (archive footage) (uncredited)
- Ego Nwodim
- Heather
- Cheri Oteri
- Arianna
- Chris Parnell
- Dr. Piedmont / Mom Jeans husband (archive footage) (uncredited)
- Nasim Pedrad
- Secretary / 1-800-Flowers announcer / mother / friend (archive footage) (uncredited)
- Jay Pharoah
- Self
- Amy Poehler
- Janice / Mom Jeans mother (archive footage) (uncredited)
- Chris Redd
- Mason / Donald (archive footage) (uncredited)
- Tim Robinson
- Waiter
- Gena Rositano
- Gino's Pizza Rolls makeup artist
- Jon Rudnitsky
- Baby Shower son
- Maya Rudolph
- Peggy / Mom Jeans mother (archive footage) (uncredited)
- Andy Samberg
- Mother Lover singer / Gino's Pizza Rolls actor (archive footage) (uncredited)
- Adam Sandler
- Self
- Susan Sarandon
- Mother
- Rob Schneider
- Self
- Amy Schumer
- Mother / Shelby McAllister (archive footage) (uncredited)
- Molly Shannon
- Jugglette
- Martin Short
- Rupert Smythe Pennington
- Cecily Strong
- Self / Baby Shower guest / Summer (archive footage) (uncredited)
- Jason Sudeikis
- Spokesperson / father / Nick Stokes (archive footage) (uncredited)
- Emma Thompson
- Mother
- Kenan Thompson
- Self / friend (archive footage) (uncredited)
- Justin Timberlake
- Mother Lover singer
- Melissa Villaseñor
- Amy
- Michaela Watkins
- Mom Celebrity Translator mom
- Betty White
- Janice / Peggy / Clara / Dooneese's mother (archive footage) (uncredited)
- Kristen Wiig
- Dooneese / Cathleen / Mom Celebrity Translator mom / Sue (archive footage) (uncredited)
- Casey Wilson
- Mom Celebrity Translator mom
- Reese Witherspoon
- Self
- Sasheer Zamata
- Self / Baby Shower guest (archive footage) (uncredited)
