- Fred MacMurray
- Jack Gordon
- Joan Bennett
- Felice Rollins
- Zasu Pitts
- Miss Harkins
- John Howard
- Freddie Scott
- Benny Bartlett
- Waldemar Pitt III
- Grace Bradley
- Trixie La Brey
- Alan Baxter
- Curtis Palmer
- Brian Donlevy
- Dr. James L. Evarts
- Ruth Donnelly
- Vi Johnson - Stewardess
- Fred Keating
- Count Gregore Stephani
- Adrienne Marden
- Ann McKenna - Stewardess
- Dean Jagger
- Hap Waller
- Mildred Stone
- Ruth Bradford - Stewardess
- Jack Mulhall
- Horace Lander - Reservations Clerk
- Clyde Dilson
- Fat Richhauser
- Dennis O'Keefe
- Baker - Co-Pilot
- Granville Bates
- Pop Andrews
- Bruce Warren
- Tex Doyle - Pilot
- Marie Prevost
- Waitress in Omaha
- Henry Arthur
- Assistant Clerk
- Paul Barrett
- Minor Role
- Edward Biby
- Man in Hall
- John Juettner
- Co-Pilot
- Ed Schaefer
- Harry
- Charles Sherlock
- Chicago Airport Pharmacist
- Gertrude Short
- Waitress in Omaha
- Arthur Singley
- Pete Stevens - Radio Man
