Caroline Williams began her career in Texas, co-starring for revered cinema master Louis Malle in his Corpus Christi-based film, Alamo Bay (1985). She worked opposite stars Ed Harris and Amy Madigan in what was her first feature film, after only six months of training at the Studio For Actors, under the tutelage of Chris Wilson. She had established herself in the Texas movie marketplace doing commercials, industrial films and voiceover work. Following "Alamo Bay", she moved to Dallas and furthered her career, with co-stars, in The Legend of Billie Jean (1985) (dir. Matthew Robbins) and Getting Even (1986) (dir. Dwight Little). When Tobe Hooper and L.M. "Kit" Carson began casting for the sequel to Hooper's iconic The Texas Chain Saw Massacre (1974), they discovered the punkass actress, who ran screaming down the hallway of the casting office. She burst into the room, pulled the chairs from beneath the duo and played the brief dialogue, while huddled in a corner. In that often told moment, she won the role from 440 actresses from both coasts.

After the successful release of the film, she moved to Hollywood to continue her career in a mix of horror: Stepfather II (1989) (dir. Jeff Burr), Leprechaun 3 (1995) (dir. Brian Trenchard Smith) and mainstream films: Days of Thunder (1990) (dir. Tony Scott), How the Grinch Stole Christmas (2000) (dir. Ron Howard). She continues to split her efforts between series TV guest star roles, such as Grey's Anatomy (2005) (dir. Debbie Allen) and The Mentalist (2008) (dir. Charles Beeson).

Luckily, her fan base enjoys her continuing dedication to the horror genre, and recent releases, such as Shriekfest (LA) Best Thriller winner Greenlight and the upcoming Ten Minutes To Midnight continue her influence within the genre.