In a career spanning over 30 years, Holt McCallany has worked with some of the world's best directors including David Fincher, Guillermo Del Toro, David O'Russell, Guy Ritchie, William Friedkin, Lawrence Kasdan, Walter Hill, Clint Eastwood, David Twohy, Brian De Palma, and Michael Mann among others.

Holt starred in the Netflix series Mindhunter as Bill Tench, an FBI agent researching serial killers in the late 1970s, and has appeared in memorable roles in Fight Club, Three Kings, Alien III, and Men of Honor to name but a few. In 2011, Holt was the star of the raw and gritty FX series Light's Out where he played a boxer with pugilistic dementia.

Born into a theatrical family, Holt's father, Michael, was a Tony Award winning Broadway producer and his mother was the legendary cabaret singer Julie Wilson. At 14, Holt ran away from home and took a Greyhound bus to Hollywood with dreams of becoming an actor, but his parents tracked him down and sent him to a boarding school in Ireland.

At 18, Holt traveled to France where he studied French at the Sorbonne, art at The Paris American Academy and, later, theater at L'École Marcel Marceau and L'École Jacques Lecoq. He went on to study Shakespeare at Oxford and later worked extensively in theater in the United States and abroad.

He is unmarried and lives in New York City.