Born on January 5, 1962 in Oklahoma City, Oklahoma, Susan Elizabeth "Suzy" Amis first worked as a Ford model before she began acting in the 1980s. She made her film debut in the comedy film Fandango (1985), opposite Kevin Costner. After that, Amis next had roles in Rocket Gibraltar (1988), Where the Heart Is (1990), Rich in Love (1992) and The Ballad of Little Jo (1993). She later appeared in Blown Away (1994), The Usual Suspects (1995) and Titanic (1997) in which she played Rose DeWitt Bukater's granddaughter Lizzy Calvert. That same year, she starred opposite Tom Selleck in the television Western Last Stand at Saber River (1997) and appeared in the horror film Nadja (1994). Amis retired from acting after her last appearance in the science fiction action film Judgment Day (1999).

In 2005, Amis founded Muse Elementary, a Reggio-inspired, independent, non-profit school in the Topanga, California area of Los Angeles.