Ulf von Euler was a noted Swedish physiologist who was one of the joint winners of the 1970 Nobel Prize in Physiology or Medicine for his work on the study of the mechanics of nerve impulses. He belonged to a family that had great academic lineage. Both his parents were distinguished scientists; his father was the recipient of Nobel Prize for Chemistry in 1929. His maternal grandfather discovered the chemical elements thulium and holmium and Leonhard Euler, the great mathematician and physicist, was his great-great-great-great grandfather. Brought up in such an environment, it became evident from early childhood that he too would follow their footsteps. After passing out from school he enrolled at Karolinska Institute to study medicine; but was very soon drawn to research. There he worked with Göran Liljestrand and on his recommendation not only obtained appointment as Assistant Professor at his alma mater soon after obtaining his doctoral degree, but also a postdoctoral fellowship to study abroad. He seized the opportunity to work with distinguished scientists at England, Belgium and Germany. His first discovery was made during this period; working with rabbits he discovered ‘substance-P’. Later he discovered four other endogenous active substances called ‘prostaglandin’, ‘vesiglandin’, ‘piperidine’ and ‘noradrenaline’. It was his discovery of the last mentioned substance that earned him the Nobel Prize. Simultaneously, he was also a great teacher and mentor. Towards the end of his life, he was referred as the “grand old man” of chemical information transfer and signaling.