Edwin G. Krebs was a noted American biochemist, who, along with Edmond H. Fischer, won the 1992 Nobel Prize in Physiology or Medicine. Krebs lost his father when he was only fifteen years old and the incident had a sad repercussion on his otherwise happy childhood. He started thinking what to do with his life even when he was a high school student. Ultimately, he entered the Washington University School of Medicine and earned his medical degrees at the age of twenty five. After a short military service, he was drawn to basic research and joined University of Washington, Seattle as an Assistant Professor at the Department of Biochemistry. There with Edmond H. Fischer, he began to work on enzymology of phosphorylase and within a short time, discovered a biochemical process called reversible protein phosphorylation, which earned them the coveted Nobel Prize many years later. Later, they worked separately on different aspect of the process. He was blessed with a keen intellect. His amazing research output earned him an iconic status among his the scientific fraternity. He was also a loving mentor to numerous students and postdoctoral fellows. Many of them still remember him as a kind and gentle mentor.