The Emmy Award-winning actor stars in NBC's Emmy and Golden Globe nominated drama series This Is Us (2016). For his role as Randall Pearson, Brown won an Emmy for Outstanding Lead Actor in a Drama Series, as well as a Golden Globe, becoming the first African-American actor to win his category in the award show's 75-year history. Additionally, Brown made history by becoming the first African-American actor to receive the SAG Award for Outstanding Male Actor in a Drama and also received a SAG award alongside his cast for Outstanding Performance by an Ensemble in a Drama Series. He also has won an NAACP Image Award and Critics Choice Award, and has been nominated for a TCA Award and a Teen Choice Award. In 2016, Brown portrayed prosecutor Christopher Darden in FX's highly-rated award-winning television event series Inside Look: The People v. O.J. Simpson - American Crime Story (2016). He won an Emmy Award and Critics Choice Award for the role and was nominated for a Golden Globe, SAG Award, and NAACP Image Award.

Brown was born in St. Louis, Missouri to Aralean Banks and Sterling Brown. His father died when he was ten, after a heart attack. Brown graduated with a Bachelor of Arts in Drama from Stanford University, before receiving his Master's Degree in Fine Arts from NYU's Tisch School of the Arts. He resides in Los Angeles with his wife and two sons.

Brown can be seen in Marvel's Black Panther (2018). Later in the year, he co-starred in Fox's The Predator (2018) and Hotel Artemis (2018), with Jodie Foster and Brian Tyree Henry. In 2017, Brown co-starred in Open Road's Marshall (2017), for which he received an NAACP Image Award nomination for his role. In 2016, Brown co-starred with Tina Fey in Paramount's Whiskey Tango Foxtrot (2016).

A lover of theater, Brown has performed in a variety of staged shows, including NY and LA productions of Father Comes Home from the Wars (Parts 1, 2, & 3), for which he won an NAACP Theatre Award and was nominated for an Ovation Award. His additional stage credits include MacBeth, The Brother/Sister Plays and The Resistible Rise of Arturo Ui opposite Al Pacino.

For seven years, Brown portrayed Dr. Roland Burton in the critically acclaimed Lifetime series Army Wives (2007). Additional television credits include Supernatural (2005), Person of Interest (2011), Masters of Sex (2013), Castle (2009) and Criminal Minds (2005). His film credits include Our Idiot Brother (2011), The Suspect (2013), Righteous Kill (2008), Trust the Man (2005), and Spaceman (2016).