Anna Kay Faris was born on November 29, 1976 in Baltimore, Maryland, to Karen (Bathurst), a special education teacher, and Jack Faris, a sociologist. She was raised in Edmonds, Washington. Her ancestry includes English, German, Scottish, French, Dutch, Irish, and Welsh. Anna started acting very young but not professionally. She loved watching theatrical plays and eventually produced one of her own with all the neighborhood children, in her immediate environment. She was always encouraged with the emphasis that she wasn't just "pretending" but rather being an unpaid producer, director, writer and an actress.

Her first paid job was at the Seattle Repertory Theatre at age nine. She loved it and did other local plays and readings. After graduating from the University of Washington in English Literature, she decided to leave for London to work and write, but after filming (the less than wonderful) Lovers Lane (2000) and a short for the Seattle Film Festival, she decided to give Los Angeles a try. She signed up with a wonderful management agency and before she could catch her breath, Keenen Ivory Wayans cast her in heavy, hard, and comedic movie (To some people, it is almost too horrific.), Scary Movie (2000) and its sequels.

She never takes anything for granted and just feels so very fortunate to have been given a chance. (An example was her trying to thank all the journalists and photographers that came to the New York premiere.)

Anna was married to actor Chris Pratt in 2009. They have a son. They separated in 2017 and were divorced in November, 2018.