Makrand Deshpande was born in Dahanu, Maharashtra, India. He is known for his work on Hanan (2004), Company (2002), Danav (2003), Swades (2004), Sarfarosh (1999), Satya (1998), Darna Zaroori Hai (2006), Chameli (2003), Market (2003), and Jungle (2000). His contribution to the theatre industry includes over 50 short plays and 40 full-length plays, including Sir Sir Sirla, Joke, Maa In Transit, Krishna Kidding and Shakepearcha Mhatara.
