Mohamed Ramadan began acting while at school. He has received the award for greatest nationwide talent three times consecutively - an unprecedented achievement. He started his career with small roles in TV series like "The Cinderella," until he had his big break in Yousry Nasrallah's "Ehky Ya Scheherazade" (Scheherazade, Tell me a story). He then went on to star in blockbusters produced by the the famous Egyptian producers Mohamed and Ahmed El Sobky, which made him one of the most valuable actors in the middle east. Mohamed Ramadan is perhaps the only Egyptian actor to have been praised by the internationally renowned performer 'Omar El-Sherif who stated that he had chosen Mohamed to perpetuate his acting legacy.