Caterina Murino was born on September 15, 1977, in Cagliari, Sardinia, Italy. In 1996 she took fourth place in the Miss Italy contest. Then she moved to Milan, where she began working as a model in commercials for MasterCard, Swatch, Mercedes-Benz and Nescafe, among other gigs. From 1999-2000 she studied acting at the Scuola di Cinema e Teatro di Francesca de Sapio in Italy.

In 1999 she made her acting debut in a stage production of "Richard III" and appeared in several Italian-language plays. In 2002 she began her film and television career with bit parts in Italian, German and French productions. Her breakthrough came in 2004, when she co-starred opposite Jean Reno in the French comedy L'enquête corse (2004).

She is trilingual, speaking French, English and Italian. She is a versatile actress and a good athlete. Her talents include singing, dancing tango, flamenco and oriental dances, as well as horseback riding. She co-starred as Solange, one of three Bond girls, opposite Daniel Craig in Casino Royale (2006).