Gregory Calpakis was born in Silver Spring, Maryland, USA. He is an actor, known for iZombie (2017), Gilrfriends' Guide to Divorce (2014-15), The Chris Isaak Show (2004), Andromeda (2004), Liberty Stands Still (2002), Stardom (2000) and Cold Squad (1998). Calpakis is also known for playing Det. Nicco Sevallis in 59 episodes of the police procedural television series Cold Squad, from 1999-2003.

Calpakis landed the role of Jessica Pare' lover, NHL's hockey winger Steve Bourque, in Denys Arcand's feature film Stardom (2000). Subsequently, he was chosen to play Detective Nicco Sevallis in 58 episodes of the police procedural television series Cold Squad, from 1999 to 2002. Along with his work on episodic television shows, Calpakis has appeared in 7 films working alongside such incredible talents as, John Malkovich, Greta Scacchi, Dan Aykroyd, Jessica Pare, Jamie Sheridan, Marlee Matlin, Jeff Fahey, Winston Reckert and Brian Markinson.

Calpakis is a dual US/Canadian citizen.