Odette Annable was born Odette Juliette Yustman on 10 May, 1985, in Los Angeles, California. Her mother, Lydia (Nodarse), is Cuban. Odette's father, Victor Oscar Yustman, was born in Bogotá, Colombia, of Italian and Polish Jewish descent. Odette started her career with a minor role in the movie Kindergarten Cop (1990) as "Rosa."

After graduating from Woodcrest Christian High School in Riverside, California, where she was the homecoming queen, she turned to modeling with a few roles through the years. Some of her credits include Danielle Steel's Remembrance (1996) and Dear God (1996) with a few guest appearances in Quintuplets (2004). In 2006, Odette was cast in Jennifer Lopez's South Beach (2006) where she played "Arielle Casta". She was then cast in the drama October Road (2007) as "Aubrey," which has received its second season. She has since been seen in the action monster movie Cloverfield (2008) as "Beth McIntyre".