Freddie Prinze, Jr. was born on March 8, 1976, in Los Angeles, California, to Kathy Prinze (née Kathy Elaine Barber) and comedian/actor Freddie Prinze. He is of Puerto Rican, German, English, and Irish descent. Freddie lived in Albuquerque, New Mexico, in his early life. He attended three different schools during his childhood: Eldorado, Sandia, and La Cueva. After graduating in 1994, Freddie moved to L.A. to focus on an acting career. He immediately garnered featured roles on several episodic series, one of which was an episode of The Gun (1995), in which Freddie had a four-line part playing a punk kid who brought a gun to school. "That was my big break, and I thought it was huge," says Freddie. He then went on to appear in a few after-school specials, including Too Soon for Jeff (1996) and Detention: The Siege at Johnson High (1997) co-starring Ricky Schroder and Henry Winkler.

Freddie is married to actress Sarah Michelle Gellar, with whom he has two children.