Melissa McCarthy was born in Plainfield, Illinois, to Sandra and Michael McCarthy, and was raised on her family's corn and soybean farm. She began her performing career as a stand-up comedian in New York where she appeared at the famous clubs, Stand Up New York and The Improv. She worked on her acting skills at The Actors Studio and appeared in many stage productions in the city before moving to Los Angeles in the late-1990s. She made a number of TV and movie appearances before making her big breakthrough as Sookie in Gilmore Girls (2000). A steady stream of comedy performances followed, leading to her starring role in the sitcom Mike & Molly (2010).

In the 2010s, McCarthy became known for her starring roles in the films Bridesmaids (2011), The Heat (2013), St. Vincent (2014), Spy (2015), Ghostbusters (2016), and Can You Ever Forgive Me? (2018).