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Animal Cops - Houston is the third Animal Planet series to follow the work of animal cruelty investigators. This particular series follows the animal cruelty investigators of the Houston Society for the Prevention of Cruelty to Animals (HSPCA). This team of 8 investigators works in a large area of Texas investigating reports of animal cruelty and, when necessary, removing animals from horrible abuse situations. Since these investigators do not have arrest or warrant seeking powers on their own, they work closely with local law enforcement, including the Harris County Precinct One Constable's Office. This office has permantly assigned Deputy Constable Christine Kendrick to assist the HSPCA investigators with any law enforcement issue that arises, including seeking warrents and arresting those charged with animal cruelty.

The Buena family appears to have it all: wealth, power, fame, and money. But when the father is falsely accused of a crime he didn't commit, it seems to be a shocking scam. Josephine Carter (Sheryl Cruz) has decided to unleash her evil revenge on the Buena family by plotting their destruction. They eventually lose all their wealth and holdings. Celina Buena (Kylie Padilla) finds a good, stable job with help from caring, sympathetic businessman Harry (Martin Del Rosario), but their love is tested when mysteries and secrets emerge regarding her identity: she is actually an adopted Buena, and the very one who destroyed her and the Buenas' life is her biological mother.

In a small town in Brittany, Gloria, a mother of three children, sees her life turned upside down when her husband goes to work one morning and never comes back.

The maverick German count Heinrich von Alternberg decides to adopt the more everyday nickname of Henry Altern and to earn a living working as a private investigator, discovering that he has a gift for it.

Crime Branch officer Animesh Datta is on a mission to catch the mastermind of a girl child trafficking racket in the Sunderbans. Will he be able to track down the culprit before more young girls disappear?

Alhaja Eniola Salami starts anew and sets her sights on a different position of power, fueled by revenge, regret and ruthlessness.