Ren becomes a lord to the cockroaches in the apartment. After being rejected from a fancy restaurant for being animals, Ren and Stimpy hatch a scheme to borrow human skin. Learn how to keep your toilet clean.
Stimpy becomes obsessed with a Smartphone that Ren gives him, until Ren Decides to Step in. a woman recommends Milk Pulp, even though its not very safe. Ren and Stimpy tell the story of Log and how they are produced.
Tired of seeing him be so nice to others, Ren shows Stimpy how to be a real bad boy, with a leather jacket and everything. Stimpy's surprisingly attractive, surprisingly human, mother comes to visit. Ren and Stimpy watch a horror movie.
Ren and Stimpy have to collect their $10,000 check before it expires, but the traffic will test their patience. Stimpy teaches you how to take care of and make your roommate happy.
Ren and Stimpy travel to the sea to hunt a shark. Stimpy becomes famous after having piano teeth, but he soon abandons Ren to Muddy Mudskipper. Dr. Stupid answers the question: "What's the best way to safely dispose of batteries?"
Stimpy gets sent to heaven, but Ren goes to hell instead of heaven, so Stimpy travels to hell to attempt to help Ren go to heaven. Ren and Stimpy run into trouble when the owner of the house returns after a 30-year long vacation.
Ren becomes depressed when he discovers that he is losing hair. But he finds a way to take advantage of it. Ren tells a tale of how he and Stimpy did a film starring Powdered Toast Man. Song starring Powdered Toast Man to promote his film.
When Ren and Stimpy get stuck outside the house, they have to unleash their wild instincts to survive. A genie gives Stimpy 3 wishes and he wastes two of them, Ren then does everything for he doesn't waste the last one.
Ren has to prepare for a reunion with his former love interest. Ren and Stimpy go on a plane trip, but everything goes wrong. Dr. Stupid answers the question "Why lemons are sour?"