Sherm discovers a pimple on his forehead just as his attractive study partner shows up at the house. Sherm's zit grows out of control and so does Clio's jealously over a girl making 'goo-goo eyes' at "her" man.
Sherm's grades are in the mail and Skelly is first to get hold of his report card. The bratty five-year-old threatens to show Mom his grades unless Sherm exposes the Germs' existence to Mom.
Sherm's accidental "hickey" sends Mom into a panic that lands him in the middle of Grandpa teaching him the facts of life and the Germs trying to split him like a cell.
Sherm has a choice...try for the highest score on his favorite arcade game, "Break Neck Speed" or stop the Germs from wreaking havoc throughout the arcade.
Sherm's excitement over meeting his favorite band, Pink Sludge is flushed down the toilet when Mom forces him to accompany her to the annual fertilizer festival.
In order to meet a good-looking "tough" girl, Sherm becomes the "Sherminator" and gets himself sentenced to school detention. The Germs' out-of-control antics turn Sherm's detention into a living hell.
Mom sends an embarrassed Sherm to the market to buy a feminine hygiene product. The Germs follow, destroying the store and causing Sherm and his 'girly things' to become the focus of everyone's attention.
The Germs sign Sherm up for the less than cool "Media Club". To make matters worse, he is put in charge and has a hard time shaking off the Club's nerds, until the germs come up with a face saving plan.
It's Mom's birthday and Sherm doesn't have a present. He settles on a plant, which proves to be extremely high maintenance. The Germs' offer to help results in typical "Germ Mayhem".
