Fujiko is hired to protect a jewel-studded mask worn by famed opera singer Ayan Maya from being stolen by Lupin. Complicating the matter is Lupin's nemesis Inspector Zenigata.
Fujiko becomes a teacher at an all-girls school, and immediately finds herself the target of affection from many students... including a shy girl named Isolde Brach.
Lupin and Jigen find themselves looking after a girl who was used as a living piece of art, while evading Fujiko, who desperately wants to kill her for personal reasons.
Lupin investigates a group of owl people who desire Fujiko and begins to learn more about Fujiko's past while fighting off illusions brought on by a strange drug.
As Goemon tries to look after Fujiko, Oscar disguises himself as Fujiko and frames her for various perfect crimes in an attempt to gain Zenigata's favour.
