Dr. Howard Sheinfeld is the charismatic head physician at the Clark St. Emergency Room in Chicago. Having recently finalized his second divorce, Dr. Sheinfeld is more than willing to pull a 48-hour shift instead of cooling his heels at home. The Clark St. staff welcomes their new, no-nonsense boss Dr. Eve Sheridan. Her strict policy changes clash with Dr. Sheinfeld's laid-back style, and the two must learn to work together peacefully. Meanwhile, George Jefferson himself visits the hospital to see his niece, Nurse Julie Williams.