Black Jack and Pinoko are hired by an ailing princess's bodyguard to cure her. The princess and bodyguard are in love, but a selfish emperor wants the princess for himself.
Ichinoseki, a promising gymnast, loses an arm to gangrene and through the encouragement of his friend Toshie via transistor in his arm, pursues competitive shogi and realizes who his real friends are.
Jun is paraplegic but lies to his online friend Tom that he plays baseball while Tom lies to Jun about being able to horseback ride when in reality he suffers from an illness produced blindness.
Pinoko decides to enter a relationship with a young boy named Tinq to make Black Jack jealous until he requires surgery. Unfortunately, his organs are reversed.
Black Jack visits a neighborhood to receive payment and bumps into the town mooch whose wife needs surgery but Black Jack is unable to perform because the train nearby makes the village shake, forcing the man to stop the trains himself.
Black Jack is kidnapped and put on a ship by robbers who force him to save the brother of one of the robbers who is dying from a bullet wound, but things get worse when they are shipwrecked.
Black Jack accompanies Sharaku and his sister Chiyoko on an archeological expedition with their father only to have Sharaku put under an alien's mind control.
Luna, a boy from Iru is suffering from a spinal cord injury made worse when his mother forces him to walk to enlist in the war. However, Black Jack fixes his back and helps mother and son make amends.
A flashback to how Black Jack met Pinoko as a teratoma on her twin sister- a cystic tumor that contains an undeveloped twin that her sister tries to get rid of but Pinoko won't let the doctors operate on her.
Jaw is a boy that loves to push others around but when he discovers he has a heart disease that becomes worse with strenuous activity, he has a change of heart.
The plane Black Jack and Pinoko are on encounters a snowstorm and ends up precariously balancing at the edge of a crevice. Everyone panics until the famous violinist Morozov calms them.
A robin constantly brings money to Black Jack and Black Jack learns that the man who saved the robin's spouse is ill and the robin wants Black Jack's help.
A company president asks Black Jack to pretend to be his son so he can operate on his brother, who he is not on good terms with since he abandoned the path to be a doctor.
An acupuncturist named Biwamaru heals patients with no fee and undermines Black Jack and his surgeries. However, when one of his treatments proves more harm than good, Black Jack must show him the errors of his pride and arrogance.
The police request Black Jack to restore the sight of a woman who witnessed the man who bombed a train station. However, Black Jack refuses as the surgery would only restore her sight for five minutes. Will he change his mind?
A man steals another man's face to earn his fortunes; however, the man's fortunes are gone and he is left with his mother who also turns out to be a fake.
Black Jack saves an amnesiac patient who is taken in by a truck driver who spotted her and took her to Black Jack. The two fall in love, however when the woman remembers who she once was, she leaves him.
