Ominous messages steer a man to a building's rooftop, where he executes an improbable shooting in the opener of the series following a team of people with extraordinary abilities who investigate crimes linked to others like them.
A problematic former patient of Rosen's escapes as Rosen is getting acquainted with his Department of Defense liaison, and the rest of the team tries to balance their normal lives with their work as Alphas.
During a raid against Red Flag an unknown Alpha is discovered. Gary bonds heavily with her while the rest of the team tries to define the extent of their enemies reach.
Agent Sullivan (guest star Valerie Cruz) credentials Dr. Rosen (David Strathairn) and his team as members of the Defense Criminal Investigation Service and their first case takes them to Pennsylvania where an outbreak of sudden deaths involving a local high school are suspected to be the work of an Alpha.
Dr, Rosen is forced to challenge his most cherished values when he encounters an alpha leading a personality cult who sincerely wants to create a paradise for all humanity, a dream his alpha ability may make possible. But as members of the alpha group fall under the cult leaders and he refuses to recognize he may be responsible for the illnesses among the cult members Dr. Rosen is forced to act... if he can.
As the Alpha team attempts to interrogate an alpha doctor, who wants to create more alphas, an invisible alpha attempts to abduct him. Dr. Rosen struggles to determine who is the more dangerous.
Dr. Rosen (David Strathairn) and his team must decide who to trust when Red Flag, led by Stanton Parish (guest star John Pyper-Ferguson), escalates the war on the Department of Defense.
