Summary As one of the country's largest hospitals, surgeons at University Hospital Southampton carry out over 34,000 operations every year, many of which are the last hope for their patients. Maxillofacial consultant Sanjay Sharma takes on some of the most challenging cases involving the face, jaw and mouth. Sanjay originally operated on sixty-seven-year-old Sue three years ago to remove cancer and to reconstruct her jaw. However, subsequent radiotherapy caused her to develop a rare condition that damaged blood vessels and caused the bone in the reconstruction to die. Sue's jaw has started to crumble, resulting in infections and a loss of function, including difficulty eating and speaking. Sanjay now faces the challenging task of rebuilding Sue's jaw once again. The procedure is so extensive that Sanjay will be joined in theatre by three other surgeons. As Sanjay removes dead bone and tissue from the jaw, plastic surgeon Nigel Horlock will work on Sue's leg, cutting a skin flap and section of fibula bone to form the new facial reconstruction. Because the blood vessels in Sue's neck have been damaged, the surgeons also need to create a new blood supply to Sue's face by harvesting an alternative blood vessel. This will be connected to her mammary artery and then tunneled underneath the skin to reach the neck, where it will be connected to the flap's vein and artery. When problems develop with the blood flow, Sue's reconstruction hangs in the balance. Challenging operations at Southampton also include complex gastrointestinal surgery, and Professor Tim Underwood specializes in these procedures. His patient, 67-year-old Monique, requires an esophagectomy, as she has advanced cancer in her esophagus, or swallowing tube. To potentially cure Monique, Tim will need to remove the cancerous section of her esophagus and then repurpose her stomach to create a new swallowing tube. But taking out the esophagus is not straightforward; the section where the cancer sits is stuck to the aorta, the body's biggest blood vessel, and also the pericardium, the membrane surrounding the heart. Damaging either could have fatal consequences. Even if Tim manages to free and remove the cancerous section of oesophagus, he must still successfully shape the stomach into a new swallowing tube by stapling it, pulling it up into the chest and connecting it to the remaining top end of the oesophagus in Monique's neck.

• Documentary